The Skykomish watershed covers 836 square miles and includes the North and South fork of the Skykomish River as well as the Sultan, Tye, Foss, and Miller Rivers. It is part of the Snohomish Basin, the second largest watershed in Washington State. The watershed was once primarily used for mining and logging, and was developed substantially in the wake of the Great Northern Railroad. Recreational activity has become more important to the region's economy over time. The watershed has many large tracts of protected land, including the Wild Sky Wilderness north of the town of Skykomish, which was approved by Congress in 2008.
- Counties: Chelan, King, Kittitas, Snohomish
- National Estuary Programs: Puget Sound
- Other Watersheds Upstream: None
- Other Watersheds Downstream: Snohomish